• Nepal has maintained consistently high coverage of DTP1, while closing the gap between DTP1 and DTP3 from 2000 to 2006.
  • This improvement cannot be attributed to higher total health spending per capita by Nepal, compared with other countries.
  • The country’s strong performance on vaccination was sustained despite civil unrest, a major earthquake, and other national challenges.

For the purposes of this study, we define Exemplar countries as those that have proven to be positive outliers in increasing immunization coverage (using the first dose of diphtheria, tetanus, and pertussis vaccine [DTP1] and the third dose [DTP3] as proxy indicators).1 Their success cannot be statistically attributed to economic growth, as reflected by Figure 1 below.

Nepal was selected to represent Asia as an Exemplar country due to its success in achieving high DTP3 coverage compared with its economic peers. In Figure 1, the relationship between the sociodemographic index (a composite measure identifying countries on a scale of development using education, total fertility rate, and income per capita) and DTP3 coverage in low- and middle-income countries can be seen.2,3 The observed sociodemographic index and DTP3 coverage estimates for each country are shown underlaid in light gray.

Nepal’s trajectory, shown in the blue dots along with the other Exemplar countries in vaccine delivery, shows consistently high performance in DTP3 coverage that outpaces other countries in similar settings.

Figure 1: SDI and DTP3 Coverage from 2000 to 2019 for 83 LMICs

Figure 1: SDI and DTP3 Coverage from 2000 to 2019 for 83 LMICs
IHME GBD 2019

During the 2000–2016 study period, Nepal’s total health spending per capita was similar to or lower than that of peer low-income countries that did not achieve comparable vaccination coverage. As of 2019, Nepal’s government health expenditure, as a share of total expenditure, was low relative to other countries in the region, with only Bangladesh and Pakistan spending less.4 This suggests that total health spending and global domestic product (GDP) per capita alone do not sufficiently explain Nepal’s vaccination success.

According to annual World Health Organization (WHO) and United Nations Children’s Fund (UNICEF) estimates of national immunization coverage (WUENIC) coverage data, Nepal has maintained consistently high coverage of DTP1, while narrowing the gap between DTP1 and DTP3 from 2000 to 2006 (Figure 2). A slight decline in immunization coverage occurred in the years following the 2015 earthquake (see Context section for further details). Relative to the disruption caused by the earthquake, coverage declined only slightly, which is a testament to the resilience of Nepal’s vaccine delivery system. In this analysis, we used data from both the Institute for Health Metrics and Evaluation (IHME) Global Burden of Disease5 and WUENIC because they have different strengths and limitations. However, it is worth noting that they use different approaches to estimate coverage of DTP1 and DTP3.

Figure 2: Nepal’s DTP1 and DTP3 Coverage over time

WHO/UNICEF estimates of national immunization coverage (WUENIC) and IHME GBD 2020 R1

DTP3 coverage levels improved nationwide in Nepal from 2000 to 2019. However, as with other Exemplar countries in vaccine delivery, there were variations at the subnational level, as shown in Figure 3. Most provinces saw increases in coverage over the years, particularly those in the mountain and Hill regions. The provinces that experienced the most improvement in vaccination coverage overall were Sudurpashchim Pradesh, Madhesh Pradesh, and Karnali Pradesh, whereas Bagmati Pradesh and Koshi Pradesh saw less progress. Notably, the most significant decline in no-DTP cases occurred in Sudurpashchim Pradesh, where coverage dropped. However, as of 2019, there were still pockets within southeastern provinces in the Terai, or low-lying flatland zone, region with the lowest vaccination rates.

Figure 3: Nepal’s DTP3 Coverage

Figure 3: Nepal’s DTP3 Coverage
Institute for Health Metrics and Evaluation (IHME). Child vaccination geospatial estimates, 2021.

Similarly, equity in immunization improved from 2001 to 2016, according to sociodemographic measures of wealth and maternal education as seen in Figure 4. Nepal closed the gap in DTP3 coverage by wealth quintile, with the poorest 20% of the population achieving similar or better coverage rates as wealthier populations. The country also narrowed the gap in DTP3 coverage by maternal education. In 2016, infants born to mothers with no education were more likely to be fully immunized than they would have been in 2001, with DTP3 coverage for this group increasing by almost 15%.

Figure 4: DTP3 Coverage in Nepal

Figure 4: DTP3 Coverage in Nepal
The DHS Program STATcompiler

How did Nepal achieve these improvements? In our research, we used both a qualitative and quantitative approach to generate hypotheses on the key drivers of success related to health facility readiness, intent to vaccinate, and community access within the context of governance and finance, health systems, and past and present interventions (Figure 5).6

Figure 5: Vaccine Delivery Framework

This narrative builds on an extensive body of knowledge about the essential components of an effective vaccine delivery system. We used the following two guidelines to synthesize this knowledge: the Global Routine Immunization Strategies and Practices3 describes a comprehensive framework of strategies and practices for routine immunization, and the Reaching Every District (RED) approach7 defines five strategies to equitably increase immunization coverage rates: (1) planning and management of resources, (2) reaching all eligible populations, (3) engaging with communities, (4) conducting supportive supervision, and (5) monitoring and using data for action. In addition, evaluations such as the Africa Routine Immunization System Essentials project8 and the full country evaluations9 conducted for Gavi, the Vaccine Alliance, documented factors contributing to coverage improvements. These assessments also shed light on how vaccination programs are being implemented and the various obstacles to immunization.

  1. 1
    Bednarczyk RA, Hester KA, Dixit SM, et al. Exemplars in vaccine delivery protocol: a case-study-based identification and evaluation of critical factors in achieving high and sustained childhood immunisation coverage in selected low-income and lower-middle-income countries. BMJ Open. 2022;12(4):e058321. https://doi.org/10.1136/bmjopen-2021-058321
  2. 2
    World Development Indicators. The World Bank Data Catalog. Updated October 8, 2024. Accessed October 10, 2024. https://datacatalog.worldbank.org/dataset/world-development-indicators
  3. 3
    World Health Organization (WHO). Global Routine Immunization Strategies and Practices (GRISP): A Companion Document to the Global Vaccine Action Plan (GVAP). Geneva: WHO; 2016. Accessed October 10, 2024. https://www.who.int/publications/i/item/global-routine-immunization-strategies-and-practices-(grisp)
  4. 4
    Joint Learning Network for Universal Health Coverage (JLN), Domestic Resource Mobilization (DRM) collaborative. Public Expenditure on Health in Nepal: A Narrative Summary. Nairobi: JLN DRM collaborative; 2021. Accessed October 10, 2024. https://jointlearningnetwork.org/wp-content/uploads/2021/12/Nepal-JLN-General-Gov-Expenditures-23092021.pdf
  5. 5
    Institute for Health Metrics and Evaluation. Global Burden of Disease (GBD). Accessed October 11, 2024. https://www.healthdata.org/research-analysis/gbd
  6. 6
    Phillips DE, Dieleman JL, Lim SS, Shearer J. Determinants of effective vaccine coverage in low and middle-income countries: a systematic review and interpretive synthesis. BMC Health Serv Res. 2017;17(1):681. https://doi.org/10.1186/s12913-017-2626-0
  7. 7
    World Health Organization (WHO). Reaching Every District (RED): A Guide to Increasing Coverage and Equity in All Communities in the African Region, 2017 Edition. Brazzaville: WHO; 2017. Accessed October 10, 2024. https://www.afro.who.int/publications/reaching-every-district-red-guide-increasing-coverage-and-equity-all-communities
  8. 8
    Africa Routine Immunization System Essentials (ARISE) project. Accessed October 10, 2024. https://arise.jsi.com/
  9. 9
    Gavi, the Vaccine Alliance. Full country evaluations. Updated February 21, 2020. Accessed October 10, 2024. https://www.gavi.org/our-impact/evaluation-studies/full-country-evaluations

Context