An Account of the Ebola Virus Disease Outbreak in Nigeria: Implications and Lessons Learnt 

Authors: Akaninyene Otu, Soter Ameh, Egbe Osifo-Dawodu, Enoma Alade, Susan Ekur, and Jide Idris

This study describes the events of the 2014 outbreak of the Ebola virus disease in Nigeria and evaluates the containment efforts. After quickly detecting an outbreak, the government traced contacts, offered incentives for medical volunteers, sent all cases to one hospital, and set up an Ebola Operations Center to manage the response. The center in turn sought help from international organizations. The government, which had already done extensive work educating the community, stepped up its efforts during the outbreak, working with the media to make sure the public always had up-to-date, accurate information. Overall, the country’s health system was geared more toward curative care than preventive medicine, but the fact that the Nigeria Centre for Disease Control had already begun training 100 doctors in epidemiology may have mitigated these weaknesses.

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Nigeria’s Ebola Outbreak Response: Lessons for Future Epidemic Preparedness 

Authors: Emmanuel Musa, Abdulsalam Nasidi, and Faisal Shuaib

In response to a 2014 Ebola outbreak in Lagos and Port Harcourt, Nigeria, the government activated an Ebola Emergency Operations Center, set up an alert and rumor management system, established treatment centers in both cities, tightened screening at ports of entry, and sent trained community mobilizers from house to house to increase awareness. Although some challenges with implementing proper treatment led to needless loss of life, Nigeria had developed excellent epidemiology systems and increased lab capacity in response to previous outbreaks, and the country was able to contain the epidemic effectively.

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Response to the First Wave of Pandemic (H1N1) 2009: Experiences and Lessons Learnt from China

Authors: W. Liang, L. Feng, C. Xu, N. Xiang, Y. Zhang, Y. Shu, H. Wang, H. Luo, H. Yu, X. Liang, D. Li, C.-K. Lee, Z. Feng, Y. Hou, Y. Wang, Z. Chen, W. Yang

In 2009, before H1N1 reached China, officials set up a response planning committee. By the time the first case was confirmed, they had already developed diagnostic kits. Tightened screening at airports and isolation slowed transmission, buying time to improve surveillance, train health care workers, and develop medicines. China contained the pandemic effectively by reserving specific hospitals, training doctors, and triaging hospital services. It also treated effectively, providing medication to all high-risk close contacts, strengthening facilities and stocks in poor areas, and making sure ethnic minorities and rural areas had access to medical relief and social security systems. Though manufacturing capability was small, China partnered with the World Health Organization to manufacture a vaccine and began a massive immunization campaign to prevent future outbreaks.

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Imported Case of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection from Oman to Thailand, June 2015

Authors: T Plipat, R Buathong, S Wacharapluesadee, P Siriarayapon, C Pittayawonganon, C Sangsajja, T Kaewpom, S Petcharat, T Ponpinit, J Jumpasri, Y Joyjinda, A Rodpan, S Ghai, A Jittmittraphap, S Khongwichit, DR Smith, VM Corman, C Drosten, T Hemachudha

In this case, the hospital faced initial challenges in both detection and containment but ultimately prevented an outbreak through extraordinary international cooperation. Detection was hampered by two false negative diagnostic tests using nasopharyngeal swabs. The patient was released from presumptive isolation on the basis of these results but returned immediately when an analysis of a sputum sample came back positive. This delay led to more complex contact tracing efforts; ultimately more than 200 contacts were identified, ranked by risk, and followed up. High-risk contacts in Thailand were quarantined, tested twice daily, and released only on the twelfth day after a negative test. The contact tracing involved steps ranging from viewing surveillance footage from a hotel in Bangkok to testing a herd of camels in Oman.

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Zero Transmission of Middle East Respiratory Syndrome: Lessons Learned From Thailand

Authors: Surasak Wiboonchutikul, Weerawat Manosuthi, and Chariya Sangsajja

The authors, staff at Bamrasnaradura Infectious Diseases Institute (BIDI), survey the range of steps BIDI has taken to prevent hospital-based, or cosonomial, transmission of disease. These measures have paid off with successful treatment of three imported MERS cases and no cosonomial transmission. Following the SARS epidemic in 2003, BIDI created appropriate infrastructure and protocols. To improve detection and containment, BIDI trained staff to screen patients presenting with acute respiratory infection, built negative-pressure isolation rooms for patients flagged at screening, and built a biosafety level 2 laboratory for rapid, safe diagnosis. Despite uncertainties about precisely how MERS spreads, BIDI adheres to the strictest protocols, including precautions against airborne and fomite (via inanimate objects like doorknobs) transmission.

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